近期Nature Communications报道了一项重要突破：研究者成功开发出一种能精准“遥控”心脏起搏开关的纳米抗体NB5。本研究首次报道了一种能够从细胞外侧特异性结合并激活HCN4离子通道的纳米抗体NB5。这项工作不仅为治疗心脏起搏功能障碍提供了全新的候选治疗策略，更重要的是，它揭示了一种 “非经典”的电机械耦合机制，挑战了对HCN通道门控原理的传统认知。接下来我们就一起来看一下这项研究以及它的意义。
A recent report in Nature Communications highlights a significant breakthrough: researchers have successfully developed a nanobody named NB5 capable of precisely "remotely controlling" the heart's pacemaking switch.This study reports for the first time a nanobody, NB5, that can specifically bind to and activate the HCN4 ion channel from the…
A recent report in Nature Communications highlights a significant breakthrough: researchers have successfully developed a nanobody named NB5 capable of precisely "remotely controlling" the heart's pacemaking switch.This study reports for the first time a nanobody, NB5, that can specifically bind to and activate the HCN4 ion channel from the extracellular side. This work not only provides a novel candidate therapeutic strategy for treating cardiac pacemaking dysfunction but, more importantly, reveals a "non-canonical" electromechanical coupling mechanism, challenging the traditional understanding of HCN channel gating principles.Let's take a closer look at this research and its significance.