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GZMK(Granzyme K, 颗粒酶K)是一种丝氨酸蛋白酶,属于Granzyme家族。它是细胞毒性淋巴细胞的主要效应分子之一,参与诱导靶细胞凋亡的过程。它通过水解特定肽键来发挥其酶活性,这些肽键通常位于靶细胞内的蛋白质上。通过切割这些蛋白质,GZMK可以触发细胞凋亡程序,导致靶细胞死亡。这使得GZMK在免疫系统清除被感染的细胞或癌细胞等过程中起着重要作用[1]。

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20世纪70年代,科学家发现了第一种肠促胰岛素激素GIP,随后又发现了第二种肠促胰岛素激素:胰高血糖素样肽-1,即GLP-1。其由小肠远端和近端结肠的肠道L细胞分泌,由胰高血糖素原基因编码,是一种由30个氨基酸组成的多肽[1-3]。
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