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GZMK(Granzyme K, 颗粒酶K)是一种丝氨酸蛋白酶，属于Granzyme家族。它是细胞毒性淋巴细胞的主要效应分子之一，参与诱导靶细胞凋亡的过程。它通过水解特定肽键来发挥其酶活性，这些肽键通常位于靶细胞内的蛋白质上。通过切割这些蛋白质，GZMK可以触发细胞凋亡程序，导致靶细胞死亡。这使得GZMK在免疫系统清除被感染的细胞或癌细胞等过程中起着重要作用[1]。
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A New Hope for Bradycardia? Nanobody Agonist NB5 Successfully Increases Pacing Frequency in Human-Derived Cardiomyocytes
A recent report in Nature Communications highlights a significant breakthrough: researchers have successfully developed a nanobody named NB5 capable of precisely "remotely controlling" the heart's...
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Currently, for diseases like FEVR, existing methods (laser, surgery) can only address complications (such as bleeding, detachment) but cannot fundamentally correct vascular developmental defects....
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Yes-associated protein (YAP) is an oncoprotein that exists in an inactive form in the cytoplasm. As a key effector of the Hippo signaling pathway, it plays a central role in cell proliferation and...
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