CD7 is a transmembrane glycoprotein primarily expressed on the surface of T cells, NK cells, and their precursor cells. It is highly expressed, especially in hematological tumors such as T-cell acute lymphoblastic leukemia (T-ALL) and lymphoma. As a member of the immunoglobulin superfamily, CD7 is involved in T cell activation, adhesion, and…
CD7 is a transmembrane glycoprotein primarily expressed on the surface of T cells, NK cells, and their precursor cells. It is highly expressed, especially in hematological tumors such as T-cell acute lymphoblastic leukemia (T-ALL) and lymphoma. As a member of the immunoglobulin superfamily, CD7 is involved in T cell activation, adhesion, and signal transduction, playing an important role in lymphocyte development and immune response. It is a significant marker for T-cell malignancies. Due to its specific expression and persistence in pathological states, CD7 has become an ideal target for developing novel immunotherapeutic strategies.
水泡性口炎病毒（VSV）是极具潜力的溶瘤病毒，可优先在干扰素通路缺陷的肿瘤细胞中复制并实现溶瘤效果，其糖蛋白（VSV-G）是慢病毒伪型最常用的包膜糖蛋白，被广泛用于基因治疗领域的研究。然而VSV-G的天然受体(LDL-R家族)在几乎所有细胞表面均有表达，导致VSV和伪型慢病毒缺乏靶向性，不仅会感染正常细胞引发脱靶毒性，还会降低体内精准治疗效果。已知VSV-G的K47和R354位点突变可完全消除其与LDL-R的结合，但保留融合活性，为改造VSV-G靶向性提供了可能。
Vesicular stomatitis virus (VSV) is a highly promising oncolytic virus capable of preferentially replicating in and lysing tumor cells with defective interferon signaling pathways. Its glycoprotein (VSV-G) is the most commonly used envelope glycoprotein for pseudotyping lentiviral vectors and is widely utilized in gene therapy research. However,…
Vesicular stomatitis virus (VSV) is a highly promising oncolytic virus capable of preferentially replicating in and lysing tumor cells with defective interferon signaling pathways. Its glycoprotein (VSV-G) is the most commonly used envelope glycoprotein for pseudotyping lentiviral vectors and is widely utilized in gene therapy research. However, the natural receptors of VSV-G (the LDL-R family) are expressed on the surface of nearly all cell types, leading to a lack of targeting specificity for both VSV and pseudotyped lentiviruses. This not only results in the infection of normal cells, causing off-target toxicity, but also reduces the efficacy of precise in vivo treatments. It is known that mutations at the K47 and R354 residues of VSV-G can completely abolish its binding to LDL-R while preserving its fusion activity, offering a potential strategy for engineering targeted VSV-G.
CD8是一种膜结合糖蛋白，广泛表达于细胞毒性T细胞（CD8+T细胞）、部分自然杀伤（NK）细胞及胸腺细胞发育阶段的特定群体上。它通常以α链和β链的异二聚体形式存在，作为T细胞受体（TCR）的共受体，与主要组织相容性复合体I类分子（MHC-I）结合，增强TCR与抗原肽-MHC复合物的亲和力，从而促进下游信号传导和T细胞激活。CD8在免疫应答中发挥关键作用，是机体清除病毒感染细胞和肿瘤细胞的重要效应分子之一。由于其在免疫调控中的核心地位，CD8成为肿瘤免疫治疗、免疫细胞研究及免疫调控机制探索中的重要靶点。
CD8 is a membrane-bound glycoprotein widely expressed on cytotoxic T cells (CD8⁺ T cells), certain subsets of natural killer (NK) cells, and specific populations during thymocyte development. It typically exists as a heterodimer of an alpha and a beta chain, functioning as a co-receptor for the T-cell receptor (TCR). It binds to Major…
CD8 is a membrane-bound glycoprotein widely expressed on cytotoxic T cells (CD8⁺ T cells), certain subsets of natural killer (NK) cells, and specific populations during thymocyte development. It typically exists as a heterodimer of an alpha and a beta chain, functioning as a co-receptor for the T-cell receptor (TCR). It binds to Major Histocompatibility Complex class I (MHC-I) molecules, enhancing the affinity of the TCR for the peptide-MHC complex, thereby promoting downstream signal transduction and T cell activation. CD8 plays a critical role in immune responses and is one of the key effector molecules for the body to clear virus-infected cells and tumor cells. Due to its central role in immune regulation, CD8 has become an important target in tumor immunotherapy, immune cell research, and the exploration of immune regulatory mechanisms.