The main pathological feature of tissue fibrosis is the excessive proliferation of fibrous connective tissue in organ tissues, accompanied by a reduction in parenchymal cells, resulting in tissue lesions. If this condition progresses continuously without intervention, it can lead to structural damage and functional decline of organs, and in severe cases, even death ^[1].

Modern medicine holds that psoriasis is a chronic skin disease caused by multiple factors such as genetic and environmental factors. Similar to lupus erythematosus mentioned earlier in some aspects, it involves immune - mediated factors, which play a crucial role in the occurrence and development of psoriasis.

Approximately 8% of the DNA in the human body is derived from the remnants of retroviruses that infected ancient human ancestors. These retroviruses reverse-transcribed their own RNA into DNA, which integrated into the human genetic material and has been inherited by humans to the present day.

Lupus erythematosus is a chronic and relapsing autoimmune disease, commonly affecting women aged 20–40 years. Based on the site of pathological involvement, it is classified into cutaneous lupus erythematosus (CLE), which is confined to the skin, and systemic lupus erythematosus (SLE), which affects multiple organs throughout the body.